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However, as cysteine serves as a rate-limiting precursor for both glutathione biosynthesis and disulfide bond formation in the endoplasmic reticulum (ER), this redirection of cysteine, despite minimal changes in extracellular cysteine levels, can reduce the pool available for efficient IgG folding 41

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doi: 10.1016/j.actbio.2022.03.001

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In addition to providing colonic epithelial cells with an energy substrate to sustain barrier function, butyrate also promotes Treg cell development via HDAC inhibitionmediated histone H3K27 acetylation at the Foxp3 gene locus (193195)

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